HTLV1 Target gene Detail Information

> TUBA1A Gene Search Result

Gene Information

Gene Name	TUBA1A
Gene ID	7846
Gene Full Name	tubulin alpha 1a
Gene Alias	LIS3; TUBA3; B-ALPHA-1
Transcripts	ENSG00000167552
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Microtubules;
HPA Protein Class Info	Cancer-related genes, Disease related genes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID	Q71U36
HGNC ID	HGNC:20766
VEGA ID	OTTHUMG00000169511
OMIM ID	602529
String ID	9606.ENSP00000301071
Drugbank ID	BE0001340
PharmGKB ID	PA162407319

Target gene [TUBA1A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6003292	chr12	150	19		169	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TUBA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
TUBA1A expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TUBA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
TUBA1A expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of TUBA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
TUBA1A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).