HBV Target gene Detail Information

> TTR Gene Search Result

Gene Information

Gene Name	TTR
Gene ID	7276
Gene Full Name	transthyretin
Gene Alias	CTS; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651
Transcripts	ENSG00000118271
Virus	HBV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID	P02766
HGNC ID	HGNC:12405
VEGA ID	OTTHUMG00000131984
OMIM ID	176300
String ID	9606.ENSP00000237014
Drugbank ID	BE0000337
PharmGKB ID	PA37069
FDA Approved Drug	Inotersen;Patisiran;Tafamidis

Target gene [TTR] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1006346	chr18	29	9	2	40	View
1012436	chr18	5	2		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TTR expression and immune infiltrating cell level correlation result in HBV+ samples
TTR expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).