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HTLV1 Target gene Detail Information

> TTC21A Gene Search Result


Gene Information
Gene Name TTC21A
Gene ID 199223
Gene Full Name tetratricopeptide repeat domain 21A
Gene Alias STI2; IFT139A
Transcripts ENSG00000168026
Virus HTLV1
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID Q8NDW8
HGNC ID HGNC:30761
VEGA ID OTTHUMG00000155973
OMIM ID 611430
String ID 9606.ENSP00000398211
PharmGKB ID PA134915959
Target gene [TTC21A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6009704 chr3 18 13 4 35 View
6012385 chr3 18 3 2 23 View
6019350 chr3 7 1 8 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of TTC21A expression and immune infiltrating cell level correlation result in HTLV1+ samples
TTC21A expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of TTC21A expression and immune infiltrating cell level correlation result in HTLV1+ samples
TTC21A expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of TTC21A expression and immune infiltrating cell level correlation result in HTLV1+ samples
TTC21A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).