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HPV Target gene Detail Information

> TSPAN8 Gene Search Result


Gene Information
Gene Name TSPAN8
Gene ID 7103
Gene Full Name tetraspanin 8
Gene Alias CO-029; TM4SF3
Transcripts ENSG00000127324
Virus HPV
Gene Type protein coding
HPA Location Info Vesicles;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Predicted membrane proteins
Uniport_ID P19075
HGNC ID HGNC:11855
VEGA ID OTTHUMG00000169542
OMIM ID 600769
String ID 9606.ENSP00000377003
PharmGKB ID PA36556
Target gene [TSPAN8] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5402771 chr12 30 19 3 52 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of TSPAN8 expression and immune infiltrating cell level correlation result in HPV+ samples
TSPAN8 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of TSPAN8 expression and immune infiltrating cell level correlation result in HPV+ samples
TSPAN8 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of TSPAN8 expression and immune infiltrating cell level correlation result in HPV+ samples
TSPAN8 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of TSPAN8 expression and immune infiltrating cell level correlation result in HPV+ samples
TSPAN8 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of TSPAN8 expression and immune infiltrating cell level correlation result in HPV+ samples
TSPAN8 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).