HTLV1 Target gene Detail Information

> TSPAN18 Gene Search Result

Gene Information

Gene Name	TSPAN18
Gene ID	90139
Gene Full Name	tetraspanin 18
Gene Alias	TSPAN
Transcripts	ENSG00000157570
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins
Uniport_ID	Q96SJ8
HGNC ID	HGNC:20660
VEGA ID	OTTHUMG00000163883
String ID	9606.ENSP00000339820
PharmGKB ID	PA142670688

Target gene [TSPAN18] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6010471	chr11	11	7	13	31	View
6010758	chr11	28	1		29	View
6020166	chr11	7			7	View
6022230	chr11	4	1		5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TSPAN18 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TSPAN18 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TSPAN18 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TSPAN18 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of TSPAN18 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TSPAN18 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).