HIV Target gene Detail Information

> TSG101 Gene Search Result

Gene Information

Gene Name	TSG101
Gene ID	7251
Gene Full Name	tumor susceptibility 101
Gene Alias	TSG10; VPS23
Transcripts	ENSG00000074319
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoli;Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q99816
HGNC ID	HGNC:15971
VEGA ID	OTTHUMG00000167725
OMIM ID	601387
String ID	9606.ENSP00000251968
PharmGKB ID	PA38068

Target gene [TSG101] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4009064	chr11	8	4	1	13	View
4013280	chr11	2	2		4	View
4013281	chr11	2	2		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TSG101 expression and immune infiltrating cell level correlation result in HIV+ samples
TSG101 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TSG101 expression and immune infiltrating cell level correlation result in HIV+ samples
TSG101 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).