HTLV1 Target gene Detail Information

> TSEN54 Gene Search Result

Gene Information

Gene Name	TSEN54
Gene ID	283989
Gene Full Name	tRNA splicing endonuclease subunit 54
Gene Alias	PCH4; PCH5; PCH2A; sen54; SEN54L
Transcripts	ENSG00000182173
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q7Z6J9
HGNC ID	HGNC:27561
VEGA ID	OTTHUMG00000179684
OMIM ID	608755
String ID	9606.ENSP00000327487
PharmGKB ID	PA142670692

Target gene [TSEN54] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004833	chr17	89	13		102	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TSEN54 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TSEN54 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TSEN54 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TSEN54 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of TSEN54 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TSEN54 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).