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HTLV1 Target gene Detail Information

> TRPC6 Gene Search Result


Gene Information
Gene Name TRPC6
Gene ID 7225
Gene Full Name transient receptor potential cation channel subfamily C member 6
Gene Alias TRP6; FSGS2
Transcripts ENSG00000137672
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID Q9Y210
HGNC ID HGNC:12338
VEGA ID OTTHUMG00000167483
OMIM ID 603652
String ID 9606.ENSP00000340913
PharmGKB ID PA37011
Target gene [TRPC6] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6031461 chr11 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of TRPC6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRPC6 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of TRPC6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRPC6 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of TRPC6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRPC6 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).