HTLV1 Target gene Detail Information

> TRIM8 Gene Search Result

Gene Information

Gene Name	TRIM8
Gene ID	81603
Gene Full Name	tripartite motif containing 8
Gene Alias	GERP; RNF27
Transcripts	ENSG00000171206
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Vesicles;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	Q9BZR9
HGNC ID	HGNC:15579
VEGA ID	OTTHUMG00000018964
OMIM ID	606125
String ID	9606.ENSP00000302120
PharmGKB ID	PA37983

Target gene [TRIM8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6009378	chr10	37			37	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TRIM8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRIM8 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TRIM8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRIM8 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of TRIM8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRIM8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).