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HTLV1 Target gene Detail Information

> TRIM5 Gene Search Result


Gene Information
Gene Name TRIM5
Gene ID 85363
Gene Full Name tripartite motif containing 5
Gene Alias RNF88; TRIM5alpha
Transcripts ENSG00000132256
Virus HTLV1
Gene Type protein coding
HPA Location Info Cytosol;
HPA Protein Class Info Enzymes, Predicted intracellular proteins
Uniport_ID Q9C035
HGNC ID HGNC:16276
VEGA ID OTTHUMG00000066893
OMIM ID 608487
String ID 9606.ENSP00000369373
PharmGKB ID PA38109
Target gene [TRIM5] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 28420387 A149T
P30
R
S
C
 View
2 28420387 A3963T
Pol
R
S
C
 View
3 28420387 A7247G
HBZ
R
S
C
 View
4 28420387 A7247G
P30
R
S
C
 View
5 28420387 C5593A
Env
R
S
C
 View
6 28420387 C6903T
P12
R
S
C
 View
7 28420387 C7962T
Tax
R
S
C
 View
8 28420387 D140G
P30
R
S
C
 View
9 28420387 F19L
Env
R
S
C
 View
10 28420387 G7273A
P30
R
S
C
 View
11 28420387 G8211A
Tax
R
S
C
 View
12 28420387 H137Q
Env
R
S
C
 View
13 28420387 S304N
Env
R
S
C
 View
14 28420387 L27R
P30
R
S
C
 View
15 28420387 P23S
P12
R
S
C
 View
16 28420387 Q323H
Pol
R
S
C
 View
17 28420387 A221V
HBZ
R
S
C
 View
18 28420387 S13P
HBZ
R
S
C
 View
19 28420387 T5237C
Env
R
S
C
 View
20 28420387 T6908G
P30
R
S
C
 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of TRIM5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRIM5 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of TRIM5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRIM5 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of TRIM5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRIM5 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).