HTLV1 Target gene Detail Information

> TRIB1 Gene Search Result

Gene Information

Gene Name	TRIB1
Gene ID	10221
Gene Full Name	tribbles pseudokinase 1
Gene Alias	C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1
Transcripts	ENSG00000173334
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	Q96RU8
HGNC ID	HGNC:16891
VEGA ID	OTTHUMG00000165007
OMIM ID	609461
String ID	9606.ENSP00000312150
PharmGKB ID	PA134963922

Target gene [TRIB1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6005471	chr8	67	15	4	86	View
6005671	chr8	67	11	4	82	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TRIB1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRIB1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TRIB1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRIB1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of TRIB1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TRIB1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).