HIV Target gene Detail Information

> TRAF3 Gene Search Result

Gene Information

Gene Name	TRAF3
Gene ID	7187
Gene Full Name	TNF receptor associated factor 3
Gene Alias	CAP1; LAP1; CAP-1; CRAF1; IIAE5; CD40bp; RNF118
Transcripts	ENSG00000131323
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q13114
HGNC ID	HGNC:12033
VEGA ID	OTTHUMG00000171902
OMIM ID	601896
String ID	9606.ENSP00000454207
PharmGKB ID	PA36710

Target gene [TRAF3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005820	chr14	24	5		29	View
4007165	chr14	10	10		20	View
4009913	chr14	4	6		10	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TRAF3 expression and immune infiltrating cell level correlation result in HIV+ samples
TRAF3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TRAF3 expression and immune infiltrating cell level correlation result in HIV+ samples
TRAF3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).