HIV Target gene Detail Information

> TPP1 Gene Search Result

Gene Information

Gene Name	TPP1
Gene ID	1200
Gene Full Name	tripeptidyl peptidase 1
Gene Alias	CLN2; GIG1; LPIC; SCAR7; TPP-1
Transcripts	ENSG00000166340
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	O14773
HGNC ID	HGNC:2073
VEGA ID	OTTHUMG00000133404
OMIM ID	607998
String ID	9606.ENSP00000299427
PharmGKB ID	PA26600
FDA Approved Drug	Cerliponase Alfa

Target gene [TPP1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002665	chr11	85			85	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TPP1 expression and immune infiltrating cell level correlation result in HIV+ samples
TPP1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TPP1 expression and immune infiltrating cell level correlation result in HIV+ samples
TPP1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).