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HTLV1 Target gene Detail Information

> TPO Gene Search Result


Gene Information
Gene Name TPO
Gene ID 7173
Gene Full Name thyroid peroxidase
Gene Alias MSA; TPX; TDH2A
Transcripts ENSG00000277603
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P07202
HGNC ID HGNC:12015
VEGA ID OTTHUMG00000189801
OMIM ID 606765
String ID 9606.ENSP00000318820
Drugbank ID BE0000507
PharmGKB ID PA36694
Target gene [TPO] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6024691 chr2 2 1 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of TPO expression and immune infiltrating cell level correlation result in HTLV1+ samples
TPO expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of TPO expression and immune infiltrating cell level correlation result in HTLV1+ samples
TPO expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of TPO expression and immune infiltrating cell level correlation result in HTLV1+ samples
TPO expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).