HBV Target gene Detail Information

> TPH2 Gene Search Result

Gene Information

Gene Name	TPH2
Gene ID	121278
Gene Full Name	tryptophan hydroxylase 2
Gene Alias	NTPH; ADHD7
Transcripts	ENSG00000139287
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID	Q8IWU9
HGNC ID	HGNC:20692
VEGA ID	OTTHUMG00000169677
OMIM ID	607478
String ID	9606.ENSP00000329093
Drugbank ID	BE0000080
PharmGKB ID	PA128747823

Target gene [TPH2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1006913	chr12	31	1		32	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TPH2 expression and immune infiltrating cell level correlation result in HBV+ samples
TPH2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).