HBV Target gene Detail Information

> TPCN2 Gene Search Result

Gene Information

Gene Name	TPCN2
Gene ID	219931
Gene Full Name	two pore segment channel 2
Gene Alias	TPC2; SHEP10
Transcripts	ENSG00000162341
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoli;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID	Q8NHX9
HGNC ID	HGNC:20820
VEGA ID	OTTHUMG00000167898
OMIM ID	612163
String ID	9606.ENSP00000294309
PharmGKB ID	PA134937857

Target gene [TPCN2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1001241	chr11	614	154	96	864	View
1006871	chr11	1	6	26	33	View
1008918	chr11	17	1		18	View
1401223	chr11	17	1		18	View
1401224	chr11	614	154	96	864	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of TPCN2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
TPCN2 expression: Low -> High
Lollipop of TPCN2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of TPCN2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TPCN2 expression and immune infiltrating cell level correlation result in HBV+ samples
TPCN2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).