HIV Target gene Detail Information

> TP53BP1 Gene Search Result

Gene Information

Gene Name	TP53BP1
Gene ID	7158
Gene Full Name	tumor protein p53 binding protein 1
Gene Alias	p202; 53BP1; TDRD30; p53BP1
Transcripts	ENSG00000067369
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear bodies;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q12888
HGNC ID	HGNC:11999
VEGA ID	OTTHUMG00000059757
OMIM ID	605230
String ID	9606.ENSP00000371475
PharmGKB ID	PA36680

Target gene [TP53BP1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4007874	chr15	10	7		17	View
4009533	chr15	11			11	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TP53BP1 expression and immune infiltrating cell level correlation result in HIV+ samples
TP53BP1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TP53BP1 expression and immune infiltrating cell level correlation result in HIV+ samples
TP53BP1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).