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HTLV1 Target gene Detail Information

> TOX3 Gene Search Result


Gene Information
Gene Name TOX3
Gene ID 27324
Gene Full Name TOX high mobility group box family member 3
Gene Alias CAGF9; TNRC9
Transcripts ENSG00000103460
Virus HTLV1
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
HPA Protein Class Info Predicted intracellular proteins, Transcription factors
Uniport_ID O15405
HGNC ID HGNC:11972
VEGA ID OTTHUMG00000173222
OMIM ID 611416
String ID 9606.ENSP00000219746
PharmGKB ID PA162406752
Target gene [TOX3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6021236 chr16 4 2 6 View
6022136 chr16 4 1 5 View
6024493 chr16 2 1 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of TOX3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TOX3 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of TOX3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TOX3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).