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HBV Target gene Detail Information

> TOX Gene Search Result


Gene Information
Gene Name TOX
Gene ID 9760
Gene Full Name thymocyte selection associated high mobility group box
Gene Alias TOX1
Transcripts ENSG00000198846
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoli fibrillar center;Nucleoplasm;
HPA Protein Class Info Predicted intracellular proteins, Transcription factors
Uniport_ID O94900
HGNC ID HGNC:18988
VEGA ID OTTHUMG00000164331
OMIM ID 606863
String ID 9606.ENSP00000354842
PharmGKB ID PA162406704
Target gene [TOX] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002960 chr8 172 11 183 View
1003351 chr8 95 21 26 142 View
1007276 chr8 26 1 1 28 View
1018438 chr8 0 View
1402991 chr8 26 1 1 28 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of TOX expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
TOX expression: Low -> High
Lollipop of TOX expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of TOX expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of TOX expression and immune infiltrating cell level correlation result in HBV+ samples
TOX expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).