HBV Target gene Detail Information

> TOP3A Gene Search Result

Gene Information

Gene Name	TOP3A
Gene ID	7156
Gene Full Name	DNA topoisomerase III alpha
Gene Alias	TOP3; PEOB5; ZGRF7; MGRISCE2
Transcripts	ENSG00000284238
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Enzymes, Predicted intracellular proteins
Uniport_ID	Q13472
HGNC ID	HGNC:11992
VEGA ID	OTTHUMG00000059391
OMIM ID	601243
String ID	9606.ENSP00000442336
PharmGKB ID	PA36673

Target gene [TOP3A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1011261	chr17	8	1		9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of TOP3A expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
TOP3A expression: Low -> High
Lollipop of TOP3A expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of TOP3A expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TOP3A expression and immune infiltrating cell level correlation result in HBV+ samples
TOP3A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).