HIV Target gene Detail Information

> TOP2B Gene Search Result


Gene Information
Gene Name TOP2B
Gene ID 7155
Gene Full Name DNA topoisomerase II beta
Gene Alias TOPIIB; top2beta
Transcripts ENSG00000077097
Virus HIV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID Q02880
HGNC ID HGNC:11990
VEGA ID OTTHUMG00000155596
OMIM ID 126431
String ID 9606.ENSP00000396704
Drugbank ID BE0002425
PharmGKB ID PA36672
Target gene [TOP2B] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4014212 chr3 2 2 View
4014455 chr3 2 2 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of TOP2B expression and immune infiltrating cell level correlation result in HIV+ samples
TOP2B expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of TOP2B expression and immune infiltrating cell level correlation result in HIV+ samples
TOP2B expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).