HIV Target gene Detail Information

> TOP2A Gene Search Result

Gene Information

Gene Name	TOP2A
Gene ID	7153
Gene Full Name	DNA topoisomerase II alpha
Gene Alias	TOP2; TP2A
Transcripts	ENSG00000131747
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Nucleoli;
HPA Protein Class Info	Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P11388
HGNC ID	HGNC:11989
VEGA ID	OTTHUMG00000155008
OMIM ID	126430
String ID	9606.ENSP00000411532
Drugbank ID	BE0000742
PharmGKB ID	PA354

Target gene [TOP2A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004718	chr17	39	1		40	View
4005321	chr17	28	6		34	View
4007910	chr17	16	1		17	View
4008054	chr17	14	2		16	View
4008153	chr17	16			16	View
4008373	chr17	12	3		15	View
4010839	chr17	7	1		8	View
4011133	chr17	4	3		7	View
4011215	chr17	5	2		7	View
4011456	chr17	6	1		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TOP2A expression and immune infiltrating cell level correlation result in HIV+ samples
TOP2A expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TOP2A expression and immune infiltrating cell level correlation result in HIV+ samples
TOP2A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).