HIV Target gene Detail Information

> TOP1 Gene Search Result

Gene Information

Gene Name	TOP1
Gene ID	7150
Gene Full Name	DNA topoisomerase I
Gene Alias	TOPI
Transcripts	ENSG00000198900
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli fibrillar center;Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID	P11387
HGNC ID	HGNC:11986
VEGA ID	OTTHUMG00000033057
OMIM ID	126420
String ID	9606.ENSP00000354522
Drugbank ID	BE0000971
PharmGKB ID	PA353

Target gene [TOP1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000213	chr20	501	83	138	722	View
4001407	chr20	91	55	23	169	View
4001651	chr20	69	56	19	144	View
4003497	chr20	16	44		60	View
4003510	chr20	39	10	11	60	View
4004064	chr20	39	11		50	View
4004065	chr20	39	11		50	View
4006695	chr20	8	11	4	23	View
4007516	chr20	10	8	1	19	View
4009625	chr20	9	2		11	View
4010377	chr20	9			9	View
4013671	chr20	1	2		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TOP1 expression and immune infiltrating cell level correlation result in HIV+ samples
TOP1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TOP1 expression and immune infiltrating cell level correlation result in HIV+ samples
TOP1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).