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HBV Target gene Detail Information

> TNIK Gene Search Result


Gene Information
Gene Name TNIK
Gene ID 23043
Gene Full Name TRAF2 and NCK interacting kinase
Gene Alias MRT54
Transcripts ENSG00000154310
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID Q9UKE5
HGNC ID HGNC:30765
VEGA ID OTTHUMG00000159036
OMIM ID 610005
String ID 9606.ENSP00000399511
Drugbank ID BE0009353
Drug (Cytoscape Annotation) Bosutinib;Axitinib;SunitinibMalate;PazopanibHydrochloride
PharmGKB ID PA134893180
Target gene [TNIK] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1006114 chr3 34 5 4 43 View
1009590 chr3 1 13 1 15 View
1011106 chr3 6 4 10 View
1404994 chr3 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of TNIK expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
TNIK expression: Low -> High
Lollipop of TNIK expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of TNIK expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of TNIK expression and immune infiltrating cell level correlation result in HBV+ samples
TNIK expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).