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HPV Target gene Detail Information

> TNFSF4 Gene Search Result


Gene Information
Gene Name TNFSF4
Gene ID 7292
Gene Full Name TNF superfamily member 4
Gene Alias GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B
Transcripts ENSG00000117586
Virus HPV
Gene Type protein coding
HPA Location Info Nucleoplasm;Vesicles;
HPA Protein Class Info Cancer-related genes, CD markers, Disease related genes, Predicted intracellular proteins
Uniport_ID P23510
HGNC ID HGNC:11934
VEGA ID OTTHUMG00000034838
OMIM ID 603594
String ID 9606.ENSP00000281834
PharmGKB ID PA36625
Target gene [TNFSF4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5000208 chr1 339 117 137 593 View
5000209 chr1 228 211 156 595 View
5000239 chr1 166 180 129 475 View
5000292 chr1 144 150 59 353 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of TNFSF4 expression and immune infiltrating cell level correlation result in HPV+ samples
TNFSF4 expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of TNFSF4 expression and immune infiltrating cell level correlation result in HPV+ samples
TNFSF4 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of TNFSF4 expression and immune infiltrating cell level correlation result in HPV+ samples
TNFSF4 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of TNFSF4 expression and immune infiltrating cell level correlation result in HPV+ samples
TNFSF4 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of TNFSF4 expression and immune infiltrating cell level correlation result in HPV+ samples
TNFSF4 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of TNFSF4 expression and immune infiltrating cell level correlation result in HPV+ samples
TNFSF4 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of TNFSF4 expression and immune infiltrating cell level correlation result in HPV+ samples
TNFSF4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).