HIV Target gene Detail Information

> TNFRSF8 Gene Search Result

Gene Information

Gene Name	TNFRSF8
Gene ID	943
Gene Full Name	TNF receptor superfamily member 8
Gene Alias	CD30; Ki-1; D1S166E
Transcripts	ENSG00000120949
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P28908
HGNC ID	HGNC:11923
VEGA ID	OTTHUMG00000001827
OMIM ID	153243
String ID	9606.ENSP00000263932
Drugbank ID	BE0003479
PharmGKB ID	PA36616
FDA Approved Drug	Brentuximab Vedotin

Target gene [TNFRSF8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4006561	chr1	21	3		24	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TNFRSF8 expression and immune infiltrating cell level correlation result in HIV+ samples
TNFRSF8 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TNFRSF8 expression and immune infiltrating cell level correlation result in HIV+ samples
TNFRSF8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).