HIV Target gene Detail Information

> TNFRSF10B Gene Search Result

Gene Information

Gene Name	TNFRSF10B
Gene ID	8795
Gene Full Name	TNF receptor superfamily member 10b
Gene Alias	DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5
Transcripts	ENSG00000120889
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, Disease related genes, Plasma proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	O14763
HGNC ID	HGNC:11905
VEGA ID	OTTHUMG00000097826
OMIM ID	603612
String ID	9606.ENSP00000276431
Drugbank ID	BE0003433
PharmGKB ID	PA36598

Target gene [TNFRSF10B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4010771	chr8	7	1		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TNFRSF10B expression and immune infiltrating cell level correlation result in HIV+ samples
TNFRSF10B expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TNFRSF10B expression and immune infiltrating cell level correlation result in HIV+ samples
TNFRSF10B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).