HBV Target gene Detail Information

> TNF Gene Search Result

Gene Information

Gene Name	TNF
Gene ID	7124
Gene Full Name	tumor necrosis factor
Gene Alias	DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Transcripts	ENSG00000228978
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	P01375
HGNC ID	HGNC:11892
VEGA ID	OTTHUMG00000004889
OMIM ID	191160
String ID	9606.ENSP00000398698
Drugbank ID	BE0000704
PharmGKB ID	PA435

Target gene [TNF] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	17187404	G1896A	PreC	G C	View
2	31565220	I127L	X	R C	View
3	31565220	I127N	X	R C	View
4	31565220	I127S	X	R C	View
5	31565220	I127T	X	R C	View
6	31565220	K130M	X	R C	View
7	31565220	R87G	X	R C	View
8	31565220	R87W	X	R C	View
9	31565220	V131I	X	R C	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TNF expression and immune infiltrating cell level correlation result in HBV+ samples
TNF expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).