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HBV Target gene Detail Information

> TMTC2 Gene Search Result


Gene Information
Gene Name TMTC2
Gene ID 160335
Gene Full Name transmembrane and tetratricopeptide repeat containing 2
Gene Alias IBDBP1
Transcripts ENSG00000179104
Virus HBV
Gene Type protein coding
HPA Location Info Plasma membrane;Actin filaments;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Predicted membrane proteins
Uniport_ID Q8N394
HGNC ID HGNC:25440
VEGA ID OTTHUMG00000169736
OMIM ID 615856
String ID 9606.ENSP00000322300
PharmGKB ID PA142670719
Target gene [TMTC2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001846 chr12 60 218 195 473 View
1002661 chr12 24 120 86 230 View
1007495 chr12 19 7 1 27 View
1017044 chr12 1 1 View
1017045 chr12 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of TMTC2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
TMTC2 expression: Low -> High
Lollipop of TMTC2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of TMTC2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of TMTC2 expression and immune infiltrating cell level correlation result in HBV+ samples
TMTC2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).