HTLV1 Target gene Detail Information

> TMTC1 Gene Search Result

Gene Information

Gene Name	TMTC1
Gene ID	83857
Gene Full Name	transmembrane and tetratricopeptide repeat containing 1
Gene Alias	OLF; ARG99; TMTC1A
Transcripts	ENSG00000133687
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins
Uniport_ID	Q8IUR5
HGNC ID	HGNC:24099
VEGA ID	OTTHUMG00000169324
OMIM ID	615855
String ID	9606.ENSP00000442046
PharmGKB ID	PA142670718

Target gene [TMTC1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002502	chr12	19	19	199	237	View
6004708	chr12	12	57	38	107	View
6008418	chr12	38	5	2	45	View
6008689	chr12	34	7	2	43	View
6012867	chr12	18	3		21	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TMTC1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMTC1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TMTC1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMTC1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).