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HTLV1 Target gene Detail Information

> TMEM67 Gene Search Result


Gene Information
Gene Name TMEM67
Gene ID 91147
Gene Full Name transmembrane protein 67
Gene Alias MKS3; JBTS6; NPHP11; TNEM67; MECKELIN
Transcripts ENSG00000164953
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID Q5HYA8
HGNC ID HGNC:28396
VEGA ID OTTHUMG00000153119
OMIM ID 609884
String ID 9606.ENSP00000389998
PharmGKB ID PA142670780
Target gene [TMEM67] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6001087 chr8 456 112 27 595 View
6006955 chr8 61 61 View
6022626 chr8 5 5 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of TMEM67 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMEM67 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of TMEM67 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMEM67 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of TMEM67 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMEM67 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).