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HPV Target gene Detail Information

> TMEM63B Gene Search Result


Gene Information
Gene Name TMEM63B
Gene ID 55362
Gene Full Name transmembrane protein 63B
Gene Alias C6orf110
Transcripts ENSG00000137216
Virus HPV
Gene Type protein coding
HPA Location Info Actin filaments;Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Predicted membrane proteins, Transporters
Uniport_ID Q5T3F8
HGNC ID HGNC:17735
VEGA ID OTTHUMG00000014757
String ID 9606.ENSP00000259746
PharmGKB ID PA134911221
Target gene [TMEM63B] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5300191 chr6 0 View
5300192 chr6 6 8 14 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of TMEM63B expression and immune infiltrating cell level correlation result in HPV+ samples
TMEM63B expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of TMEM63B expression and immune infiltrating cell level correlation result in HPV+ samples
TMEM63B expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of TMEM63B expression and immune infiltrating cell level correlation result in HPV+ samples
TMEM63B expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).