HIV Target gene Detail Information

> TMEM59 Gene Search Result

Gene Information

Gene Name	TMEM59
Gene ID	9528
Gene Full Name	transmembrane protein 59
Gene Alias	DCF1; C1orf8; PRO195; UNQ169; HSPC001
Transcripts	ENSG00000116209
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q9BXS4
HGNC ID	HGNC:1239
VEGA ID	OTTHUMG00000008437
OMIM ID	617084
String ID	9606.ENSP00000234831
PharmGKB ID	PA25620

Target gene [TMEM59] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005128	chr1	19	16		35	View
4008367	chr1	10	4	1	15	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TMEM59 expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM59 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TMEM59 expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM59 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).