HIV Target gene Detail Information

> TMEM50A Gene Search Result

Gene Information

Gene Name	TMEM50A
Gene ID	23585
Gene Full Name	transmembrane protein 50A
Gene Alias	SMP1; IFNRC
Transcripts	ENSG00000183726
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Actin filaments;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins, Transporters
Uniport_ID	O95807
HGNC ID	HGNC:30590
VEGA ID	OTTHUMG00000007651
OMIM ID	605348
String ID	9606.ENSP00000363478
PharmGKB ID	PA142670766

Target gene [TMEM50A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4007883	chr1	12	5		17	View
4009794	chr1	10			10	View
4010367	chr1	9			9	View
4013400	chr1	1	2		3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TMEM50A expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM50A expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TMEM50A expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM50A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).