HIV Target gene Detail Information

> TMEM175 Gene Search Result

Gene Information

Gene Name	TMEM175
Gene ID	84286
Gene Full Name	transmembrane protein 175
Gene Alias	hTMEM175
Transcripts	ENSG00000127419
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear membrane;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Uniport_ID	Q9BSA9
HGNC ID	HGNC:28709
VEGA ID	OTTHUMG00000118996
OMIM ID	616660
String ID	9606.ENSP00000264771
PharmGKB ID	PA162405946

Target gene [TMEM175] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000893	chr4	91	132	31	254	View
4004538	chr4	23	20		43	View
4009088	chr4	10	3		13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TMEM175 expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM175 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TMEM175 expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM175 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).