HTLV1 Target gene Detail Information

> TMEM138 Gene Search Result

Gene Information

Gene Name	TMEM138
Gene ID	51524
Gene Full Name	transmembrane protein 138
Gene Alias	HSPC196
Transcripts	ENSG00000149483
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Microtubules;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Predicted membrane proteins
Uniport_ID	Q9NPI0
HGNC ID	HGNC:26944
VEGA ID	OTTHUMG00000168145
OMIM ID	614459
String ID	9606.ENSP00000278826
PharmGKB ID	PA144596259

Target gene [TMEM138] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6011804	chr11	25			25	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TMEM138 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMEM138 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TMEM138 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMEM138 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).