HIV Target gene Detail Information

> TMEM135 Gene Search Result

Gene Information

Gene Name	TMEM135
Gene ID	65084
Gene Full Name	transmembrane protein 135
Gene Alias	PMP52
Transcripts	ENSG00000166575
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins
Uniport_ID	Q86UB9
HGNC ID	HGNC:26167
VEGA ID	OTTHUMG00000167248
OMIM ID	616360
String ID	9606.ENSP00000306344
PharmGKB ID	PA143485658

Target gene [TMEM135] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003215	chr11	9	43	14	66	View
4007706	chr11	1	12	5	18	View
4009211	chr11	9	2	1	12	View
4016486	chr11				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TMEM135 expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM135 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TMEM135 expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM135 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).