HTLV1 Target gene Detail Information

> TMEM108 Gene Search Result

Gene Information

Gene Name	TMEM108
Gene ID	66000
Gene Full Name	transmembrane protein 108
Gene Alias	RTLN; CT124
Transcripts	ENSG00000144868
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;Nucleoli;Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q6UXF1
HGNC ID	HGNC:28451
VEGA ID	OTTHUMG00000159685
OMIM ID	617361
String ID	9606.ENSP00000324651
PharmGKB ID	PA142670759

Target gene [TMEM108] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6008533	chr3	3	40	1	44	View
6010091	chr3	25	5	3	33	View
6012849	chr3	14	7		21	View
6012850	chr3	14	7		21	View
6012851	chr3	14	7		21	View
6013117	chr3	14	6		20	View
6014900	chr3	7	8		15	View
6021096	chr3	3	3		6	View
6031922	chr3				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of TMEM108 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMEM108 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of TMEM108 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMEM108 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of TMEM108 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TMEM108 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).