HIV Target gene Detail Information

> TMEM106B Gene Search Result

Gene Information

Gene Name	TMEM106B
Gene ID	54664
Gene Full Name	transmembrane protein 106B
Gene Alias	HLD16
Transcripts	ENSG00000106460
Virus	HIV
Gene Type	protein coding
HPA Location Info	Endosomes;Lysosomes;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	Q9NUM4
HGNC ID	HGNC:22407
VEGA ID	OTTHUMG00000125537
OMIM ID	613413
String ID	9606.ENSP00000379901
PharmGKB ID	PA142670756

Target gene [TMEM106B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005968	chr7	27	1		28	View
4007592	chr7	16	2		18	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TMEM106B expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM106B expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TMEM106B expression and immune infiltrating cell level correlation result in HIV+ samples
TMEM106B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).