HIV Target gene Detail Information

> TMCO3 Gene Search Result

Gene Information

Gene Name	TMCO3
Gene ID	55002
Gene Full Name	transmembrane and coiled-coil domains 3
Gene Alias	C13orf11
Transcripts	ENSG00000150403
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	Q6UWJ1
HGNC ID	HGNC:20329
VEGA ID	OTTHUMG00000017389
OMIM ID	617134
String ID	9606.ENSP00000389399
PharmGKB ID	PA134989495

Target gene [TMCO3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003384	chr13	41	15	6	62	View
4004545	chr13	39	3		42	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TMCO3 expression and immune infiltrating cell level correlation result in HIV+ samples
TMCO3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TMCO3 expression and immune infiltrating cell level correlation result in HIV+ samples
TMCO3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).