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HBV Target gene Detail Information

> TMC1 Gene Search Result


Gene Information
Gene Name TMC1
Gene ID 117531
Gene Full Name transmembrane channel like 1
Gene Alias DFNB7; DFNA36; DFNB11
Transcripts ENSG00000165091
Virus HBV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Uniport_ID Q8TDI8
HGNC ID HGNC:16513
VEGA ID OTTHUMG00000020014
OMIM ID 606706
String ID 9606.ENSP00000297784
PharmGKB ID PA38156
Target gene [TMC1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1011729 chr9 4 4 8 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of TMC1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
TMC1 expression: Low -> High
Lollipop of TMC1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of TMC1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of TMC1 expression and immune infiltrating cell level correlation result in HBV+ samples
TMC1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).