HBV Target gene Detail Information

> TLR2 Gene Search Result

Gene Information

Gene Name	TLR2
Gene ID	7097
Gene Full Name	toll like receptor 2
Gene Alias	TIL4; CD282
Transcripts	ENSG00000137462
Virus	HBV
Gene Type	protein coding
HPA Location Info	Mitochondria;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	O60603
HGNC ID	HGNC:11848
VEGA ID	OTTHUMG00000161525
OMIM ID	603028
String ID	9606.ENSP00000260010
Drugbank ID	BE0001164
PharmGKB ID	PA36550

Target gene [TLR2] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	17187404	G1896A	PreC	G C	View
2	24187552	G1896A	PreC	G C	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TLR2 expression and immune infiltrating cell level correlation result in HBV+ samples
TLR2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: LIHC