HIV Target gene Detail Information

> TLK2 Gene Search Result

Gene Information

Gene Name	TLK2
Gene ID	11011
Gene Full Name	tousled like kinase 2
Gene Alias	HsHPK; MRD57; PKU-ALPHA
Transcripts	ENSG00000146872
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q86UE8
HGNC ID	HGNC:11842
VEGA ID	OTTHUMG00000179176
OMIM ID	608439
String ID	9606.ENSP00000316512
Drugbank ID	BE0009352
PharmGKB ID	PA36544

Target gene [TLK2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005272	chr17	4	30		34	View
4006234	chr17	19	6	1	26	View
4014713	chr17	1	1		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TLK2 expression and immune infiltrating cell level correlation result in HIV+ samples
TLK2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TLK2 expression and immune infiltrating cell level correlation result in HIV+ samples
TLK2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).