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HTLV1 Target gene Detail Information

> TIMP2 Gene Search Result


Gene Information
Gene Name TIMP2
Gene ID 7077
Gene Full Name TIMP metallopeptidase inhibitor 2
Gene Alias DDC8; CSC-21K
Transcripts ENSG00000035862
Virus HTLV1
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID P16035
HGNC ID HGNC:11821
VEGA ID OTTHUMG00000154517
OMIM ID 188825
String ID 9606.ENSP00000262768
PharmGKB ID PA36527
Target gene [TIMP2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6000832 chr17 368 270 171 809 View
6007003 chr17 60 60 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of TIMP2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TIMP2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of TIMP2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TIMP2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of TIMP2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
TIMP2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).