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HBV Target gene Detail Information

> THRB Gene Search Result


Gene Information
Gene Name THRB
Gene ID 7068
Gene Full Name thyroid hormone receptor beta
Gene Alias GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA
Transcripts ENSG00000151090
Virus HBV
Gene Type protein coding
HPA Location Info Nuclear bodies;
HPA Protein Class Info Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Gene Function Suppressor gene
Uniport_ID P10828
HGNC ID HGNC:11799
VEGA ID OTTHUMG00000130478
OMIM ID 190160
String ID 9606.ENSP00000379904
Drugbank ID BE0000315; BE0009811
PharmGKB ID PA36508
Target gene [THRB] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004100 chr3 28 27 38 93 View
1004450 chr3 29 23 29 81 View
1004526 chr3 29 22 27 78 View
1004541 chr3 29 22 27 78 View
1007510 chr3 25 2 27 View
1010015 chr3 4 4 5 13 View
1011687 chr3 7 1 8 View
1011883 chr3 2 1 5 8 View
1011884 chr3 2 1 5 8 View
1012016 chr3 7 1 8 View
1012962 chr3 4 2 6 View
1017375 chr3 1 1 View
1017376 chr3 1 1 View
1017395 chr3 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of THRB expression and immune infiltrating cell level correlation result in HBV+ samples
THRB expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).