HIV Target gene Detail Information

> THRA Gene Search Result

Gene Information

Gene Name	THRA
Gene ID	7067
Gene Full Name	thyroid hormone receptor alpha
Gene Alias	AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1
Transcripts	ENSG00000126351
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene & Oncogene
Uniport_ID	P10827
HGNC ID	HGNC:11796
VEGA ID	OTTHUMG00000133332
OMIM ID	190120
String ID	9606.ENSP00000264637
Drugbank ID	BE0000687; BE0009811
PharmGKB ID	PA36507

Target gene [THRA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000409	chr17	416	43	24	483	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of THRA expression and immune infiltrating cell level correlation result in HIV+ samples
THRA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).