HPV Target gene Detail Information

> THBS1 Gene Search Result


Gene Information
Gene Name THBS1
Gene ID 7057
Gene Full Name thrombospondin 1
Gene Alias TSP; THBS; TSP1; TSP-1; THBS-1
Transcripts ENSG00000137801
Virus HPV
Gene Type protein coding
HPA Location Info Plasma membrane;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins
Gene Function Suppressor gene
Uniport_ID P07996
HGNC ID HGNC:11785
VEGA ID OTTHUMG00000133665
OMIM ID 188060
String ID 9606.ENSP00000260356
PharmGKB ID PA36497
Target gene [THBS1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5400747 chr15 2 6 8 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of THBS1 expression and immune infiltrating cell level correlation result in HPV+ samples
THBS1 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of THBS1 expression and immune infiltrating cell level correlation result in HPV+ samples
THBS1 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of THBS1 expression and immune infiltrating cell level correlation result in HPV+ samples
THBS1 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).