HTLV1 Target gene Detail Information

> THBD Gene Search Result

Gene Information

Gene Name	THBD
Gene ID	7056
Gene Full Name	thrombomodulin
Gene Alias	TM; THRM; AHUS6; BDCA3; CD141; THPH12
Transcripts	ENSG00000178726
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Candidate cardiovascular disease genes, CD markers, Disease related genes, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	P07204
HGNC ID	HGNC:11784
VEGA ID	OTTHUMG00000032053
OMIM ID	188040
String ID	9606.ENSP00000366307
Drugbank ID	BE0001151
PharmGKB ID	PA36496

Target gene [THBD] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6015823	chr20	8	5		13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of THBD expression and immune infiltrating cell level correlation result in HTLV1+ samples
THBD expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of THBD expression and immune infiltrating cell level correlation result in HTLV1+ samples
THBD expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of THBD expression and immune infiltrating cell level correlation result in HTLV1+ samples
THBD expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).