HIV Target gene Detail Information

> TGFBR3 Gene Search Result

Gene Information

Gene Name	TGFBR3
Gene ID	7049
Gene Full Name	transforming growth factor beta receptor 3
Gene Alias	BGCAN; betaglycan
Transcripts	ENSG00000069702
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Predicted to be secreted;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Gene Function	Suppressor gene
Uniport_ID	Q03167
HGNC ID	HGNC:11774
VEGA ID	OTTHUMG00000010097
OMIM ID	600742
String ID	9606.ENSP00000212355
PharmGKB ID	PA36487

Target gene [TGFBR3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4007994	chr1	15	1	1	17	View
4009773	chr1	9	1		10	View
4016728	chr1				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of TGFBR3 expression and immune infiltrating cell level correlation result in HIV+ samples
TGFBR3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of TGFBR3 expression and immune infiltrating cell level correlation result in HIV+ samples
TGFBR3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).