HBV Target gene Detail Information

> TGFB1 Gene Search Result

Gene Information

Gene Name	TGFB1
Gene ID	7040
Gene Full Name	transforming growth factor beta 1
Gene Alias	CED; LAP; DPD1; TGFB; TGFbeta
Transcripts	ENSG00000105329
Virus	HBV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Cytosol;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	P01137
HGNC ID	HGNC:11766
VEGA ID	OTTHUMG00000182760
OMIM ID	190180
String ID	9606.ENSP00000221930
Drugbank ID	BE0000984
PharmGKB ID	PA350

Target gene [TGFB1] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	31565220	I127L	X	R C	View
2	31565220	I127N	X	R C	View
3	31565220	I127S	X	R C	View
4	31565220	I127T	X	R C	View
5	31565220	K130M	X	R C	View
6	31565220	R87G	X	R C	View
7	31565220	R87W	X	R C	View
8	31565220	V131I	X	R C	View
9	29609638	A181T	RT		View
10	32887289	M204I	RT		View
11	32887289	W196*	S		View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of TGFB1 expression and immune infiltrating cell level correlation result in HBV+ samples
TGFB1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: LIHC